Armstrong better, Green Day to resume tour in 2013






LOS ANGELES (AP) — Green Day is going back out on the road.


The Grammy-winning punk band announced new tour dates Monday.






The band canceled the rest of its 2012 club schedule and postponed the start of a 2013 arena tour after singer-guitarist Billie Joe Armstrong‘s substance abuse problems emerged publicly in September when he had a profane meltdown on the stage of the iHeartRadio Music Festival in Las Vegas.


Armstrong told fans in a statement Monday that he’s “getting better every day” and “the show must go on.”


The tour is scheduled to begin March 28 at the Allstate Arena in the Chicago area.


The band released its most recent album, “Tre,” on Dec. 11, more than a month ahead of schedule.


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Personal Health: Food Myths

Let’s start the new year on scientifically sound footing by addressing some nutritional falsehoods that circulate widely in cyberspace, locker rooms, supermarkets and health food stores. As a result, millions of people are squandering hard-earned dollars on questionable, even hazardous foods and supplements.

For starters, when did “chemical” become a dirty word? That’s a question raised by one of Canada’s brightest scientific minds: Joe Schwarcz, director of the Office for Science and Society at McGill University in Montreal. Dr. Schwarcz, who has received high honors from Canadian and American scientific societies, is the author of several best-selling books that attempt to set the record straight on a host of issues that commonly concern health-conscious people.

I’ve read two of his books, “Science, Sense and Nonsense” (published in 2009) and “The Right Chemistry” (2012), and recently attended a symposium on the science of food that Dr. Schwarcz organized at McGill.

What follows are tips from his books and the symposium that can help you make wiser choices about what does, and does not, pass your lips in 2013.

CURED MEATS Many health-conscious people avoid cured meats like hot dogs and bacon because the nitrites with which they are preserved can react with naturally occurring amines to form nitrosamines. Nitrosamines have produced mutations in cells cultured in the laboratory and cancer in animals treated with very high doses.

As an alternative, sandwich lovers often buy organic versions of processed meats or products without added nitrites. Without preservatives, these foods may not be protected from bacterial contamination. And despite their labels, they may contain nitrites. According to Dr. Schwarcz, organic processed meats labeled “uncured” may be preserved with highly concentrated, nitrate-rich celery juice treated with a bacterial culture that produces nitrites.

If you’re really concerned about your health, you’d be wise to steer clear of processed meats — organic, nitrite-free or otherwise. High saturated fat and salt content place them low on the nutritional totem pole.

MEAT GLUE Never heard of it? You may have eaten it, especially if you dine out often. At WD-50 in New York, the chef, Wylie Dufresne, makes his famous shrimp noodles with the enzyme transglutaminase, a k a meat glue. It binds protein molecules, gluing together small pieces of fish, meat or poultry.

The Japanese use meat glue to create artificial crab meat from pollock. Others use it to combine lamb and scallops, or to make sausages that hold together without casings.

Sound frightening? It shouldn’t. The enzyme is classified by the Food and Drug Administration as “generally recognized as safe,” and there is no reason to think otherwise. Our bodies produce it to help blood clot, Dr. Schwarcz points out. When consumed, it breaks down like any protein into its component amino acids in our digestive tracts.

There is, however, one possible indirect hazard: If glued-together animal protein is not thoroughly cooked, dangerous bacteria that originally contaminated the meat could remain viable within the fused product.

TRANS FATS The removal of heart-damaging trans fats from processed foods is a much-ballyhooed boon to health. But “not all trans fats are fiends,” Dr. Schwarcz notes. Certain ones can legally, and healthfully, be added to dairy products, meal-replacement bars, soy milk and fruit juice.

The word “trans” refers to the arrangement of hydrogen and carbon atoms in a fatty acid. The trans formation linked to heart disease is formed when vegetable oils are hardened to prolong shelf life in a manufacturing process called hydrogenation. Natural trans fats, like those in meat and dairy products, take a slightly different form, resulting in an entirely different effect on health.

The most widely consumed “good” trans fat is conjugated linoleic acid, which research has shown can help weight-conscious people lose fat and gain muscle. Various studies have suggested that C.L.A., now widely sold as a supplement, also can enhance immune function and reduce atherosclerosis, high blood pressure and inflammation.

ORGANIC OR NOT? Wherever I shop for food these days, I find an ever-widening array of food products labeled “organic” and “natural.” But are consumers getting the health benefits they pay a premium for?

Until the 20th century, Dr. Schwarcz wrote, all farming was “organic,” with manure and compost used as fertilizer and “natural” compounds of arsenic, mercury and lead used as pesticides.

Might manure used today on organic farms contain disease-causing micro-organisms? Might organic produce unprotected by insecticides harbor cancer-causing molds? It’s a possibility, Dr. Schwarcz said. But consumers aren’t looking beyond the organic sales pitch.

Also questionable is whether organic foods, which are certainly kinder to the environment, are more nutritious. Though some may contain slightly higher levels of essential micronutrients, like vitamin C, the difference between them and conventionally grown crops may depend more on where they are produced than how.

A further concern: Organic producers disavow genetic modification, which can be used to improve a crop’s nutritional content, enhance resistance to pests and diminish its need for water. A genetically modified tomato developed at the University of Exeter, for example, contains nearly 80 times the antioxidants of conventional tomatoes. Healthier, yes — but it can’t be called organic.

FARMED SALMON Most of the salmon consumed nowadays is farmed. Even if we all could afford the wild variety, there’s simply not enough of it to satisfy the current demand for this heart-healthy fish.

There may be legitimate concerns about possible pollutants in farmed salmon, but one concern that is a nonissue involves that “salmon” color, produced by adding astaxanthin to fish feed. This commercially made pigment is an antioxidant found naturally in algae, and it is carried up the food chain to give wild salmon its color, too.

NUTS Growing up, I was often warned to avoid nuts because they’re “fattening.” Now I know better. Research has shown that people who regularly eat nuts and nut butters in normal amounts weigh less, on average, than nut avoiders.

The fat in nuts is unsaturated and heart-healthy. Nuts are also good sources of protein, antioxidants, vitamins, minerals and fiber, and can help keep between-meal hunger at bay. The same is true of avocados — just don’t go overboard.

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Boehner: Obama won't stand up to his own party on 'fiscal cliff'









WASHINGTON -- House Speaker John A. Boehner called it “ironic” that President Obama blamed Republicans for stalled negotiations on the "fiscal cliff" and accused the Democrat of being unwilling to stand up to his own party.


Responding to Obama’s appearance on NBC’s “Meet The Press,” the Ohio Republican said the GOP has been “reasonable and responsible” throughout the talks.


“In an effort to get the president to agree to cut spending -- which is the problem -- I put revenues on the table last year, and I put them on the table again last month,” Boehner said in a statement. “Republicans made every effort to reach the ‘balanced’ deficit agreement that the president promised the American people, while the president has continued to insist on a package skewed dramatically in favor of higher taxes that would destroy jobs.”





In an interview taped Saturday, Obama told NBC’s David Gregory that he remained “optimistic” that a deal could be reached, but said that in his mind, the sticking point was that Republicans “have had trouble saying yes to a number of repeated offers.”


QUIZ: How much do you know about the fiscal cliff?


“Congress has not been able to get this stuff done, not because Democrats in Congress don't want to go ahead and cooperate, but because I think it's been very hard for Speaker Boehner and Republican Leader [Mitch] McConnell to accept the fact that taxes on the wealthiest Americans should go up a little bit, as part of an overall deficit reduction package,” he said.


“I negotiated with Speaker Boehner in good faith and moved more than halfway in order to achieve a grand bargain.”


Earlier this month, Obama had offered to raise the income threshold for higher tax rates to $400,000, from the $250,000 he had campaigned on. Boehner pulled back from the negotiations and tried to pass what he called "Plan B," which would have boosted the threshold to $1 million. He failed to get support from House Republicans and did not bring it to the floor.


Don Stewart, a spokesman for Senate Republican Leader Mitch McConnell, responded that “while the president was taping those discordant remarks yesterday, Sen. McConnell was in the office working to bring Republicans and Democrats together on a solution. Discussions continue today.”


In his statement, Boehner noted that the House has passed multiple bills that would avert the entire fiscal cliff, addressing both the looming across-the-board tax increases and deep spending cuts.


“The president has never called for the Senate to act on those bills in any way. He instead has simply allowed the Democratic-controlled Senate to sit on them and lead our economy to the edge of the fiscal cliff,” Boehner said.


PHOTOS: Notable moments of the 2012 presidential election


The Senate has passed budget bills that the House has not acted upon.


The House is due to gavel in Sunday afternoon, with votes expected on unrelated bills. The Senate is in session while leaders and staff continue to seek a solution that would garner enough votes to move over to the House.


“We know that there are negotiations going on,” Sen. Barbara Boxer (D-Calif.) said on the Senate floor. “I really hope our leaders can find a way out of this.”


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Wired Science's Top Image Galleries of the Year

Many of our most popular posts are image galleries, and this year our readers favorite collections included microscope photos, doomsday scenarios, auroras and lots of images of Earth from space.


The satellite image above of Brasilia is part of the most popular post of the year.


Above:

I think it's safe to say that our readers like looking at images of Earth from space almost as much as we do. Satellite imagery was the subject of four of Wired Science's 10 most popular galleries of 2012, with this gallery of planned cities topping the list.


See the full gallery.


Image: NASA/USGS

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‘The Hobbit’ stays atop box office for third week






LOS ANGELES (AP) — “The Hobbit: An Unexpected Journey” continues to rule them all at the box office, staying on top for a third-straight week with nearly $ 33 million.


The Warner Bros. fantasy epic from director Peter Jackson, based on the J.R.R. Tolkien novel, has made $ 222.7 million domestically alone.






Two big holiday movies — and potential awards contenders — also had strong openings. Quentin Tarantino‘s spaghetti Western-blaxploitation mash-up “Django Unchained” came in second place for the weekend with $ 30.7 million. The Weinstein Co. revenge epic, starring Jamie Foxx and Christoph Waltz, has earned $ 64 million since its Christmas Day opening.


And in third place with $ 28 million was the sweeping, all-singing “Les Miserables.” The Universal Pictures musical starring Hugh Jackman and Anne Hathaway has made $ 67.5 million since debuting on Christmas.


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Well: Exercise and the Ever-Smarter Human Brain

Anyone whose resolve to exercise in 2013 is a bit shaky might want to consider an emerging scientific view of human evolution. It suggests that we are clever today in part because a million years ago, we could outrun and outwalk most other mammals over long distances. Our brains were shaped and sharpened by movement, the idea goes, and we continue to require regular physical activity in order for our brains to function optimally.

Phys Ed

Gretchen Reynolds on the science of fitness.

The role of physical endurance in shaping humankind has intrigued anthropologists and gripped the popular imagination for some time. In 2004, the evolutionary biologists Daniel E. Lieberman of Harvard and Dennis M. Bramble of the University of Utah published a seminal article in the journal Nature titled “Endurance Running and the Evolution of Homo,” in which they posited that our bipedal ancestors survived by becoming endurance athletes, able to bring down swifter prey through sheer doggedness, jogging and plodding along behind them until the animals dropped.

Endurance produced meals, which provided energy for mating, which meant that adept early joggers passed along their genes. In this way, natural selection drove early humans to become even more athletic, Dr. Lieberman and other scientists have written, their bodies developing longer legs, shorter toes, less hair and complicated inner-ear mechanisms to maintain balance and stability during upright ambulation. Movement shaped the human body.

But simultaneously, in a development that until recently many scientists viewed as unrelated, humans were becoming smarter. Their brains were increasing rapidly in size.

Today, humans have a brain that is about three times larger than would be expected, anthropologists say, given our species’ body size in comparison with that of other mammals.

To explain those outsized brains, evolutionary scientists have pointed to such occurrences as meat eating and, perhaps most determinatively, our early ancestors’ need for social interaction. Early humans had to plan and execute hunts as a group, which required complicated thinking patterns and, it’s been thought, rewarded the social and brainy with evolutionary success. According to that hypothesis, the evolution of the brain was driven by the need to think.

But now some scientists are suggesting that physical activity also played a critical role in making our brains larger.

To reach that conclusion, anthropologists began by looking at existing data about brain size and endurance capacity in a variety of mammals, including dogs, guinea pigs, foxes, mice, wolves, rats, civet cats, antelope, mongooses, goats, sheep and elands. They found a notable pattern. Species like dogs and rats that had a high innate endurance capacity, which presumably had evolved over millenniums, also had large brain volumes relative to their body size.

The researchers also looked at recent experiments in which mice and rats were systematically bred to be marathon runners. Lab animals that willingly put in the most miles on running wheels were interbred, resulting in the creation of a line of lab animals that excelled at running.

Interestingly, after multiple generations, these animals began to develop innately high levels of substances that promote tissue growth and health, including a protein called brain-derived neurotrophic factor, or BDNF. These substances are important for endurance performance. They also are known to drive brain growth.

What all of this means, says David A. Raichlen, an anthropologist at the University of Arizona and an author of a new article about the evolution of human brains appearing in the January issue of Proceedings of the Royal Society Biology, is that physical activity may have helped to make early humans smarter.

“We think that what happened” in our early hunter-gatherer ancestors, he says, is that the more athletic and active survived and, as with the lab mice, passed along physiological characteristics that improved their endurance, including elevated levels of BDNF. Eventually, these early athletes had enough BDNF coursing through their bodies that some could migrate from the muscles to the brain, where it nudged the growth of brain tissue.

Those particular early humans then applied their growing ability to think and reason toward better tracking prey, becoming the best-fed and most successful from an evolutionary standpoint. Being in motion made them smarter, and being smarter now allowed them to move more efficiently.

And out of all of this came, eventually, an ability to understand higher math and invent iPads. But that was some time later.

The broad point of this new notion is that if physical activity helped to mold the structure of our brains, then it most likely remains essential to brain health today, says John D. Polk, an associate professor of anthropology at the University of Illinois at Urbana-Champaign, and co-author, with Dr. Raichlen, of the new article.

And there is scientific support for that idea. Recent studies have shown, he says, that “regular exercise, even walking,” leads to more robust mental abilities, “beginning in childhood and continuing into old age.”

Of course, the hypothesis that jogging after prey helped to drive human brain evolution is just a hypothesis, Dr. Raichlen says, and almost unprovable.

But it is compelling, says Harvard’s Dr. Lieberman, who has worked with the authors of the new article. “I fundamentally agree that there is a deep evolutionary basis for the relationship between a healthy body and a healthy mind,” he says, a relationship that makes the term “jogging your memory” more literal than most of us might have expected and provides a powerful incentive to be active in 2013.

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New NHL proposal sets Jan. 19 deadline to open season













Bill Daly, Steve Fehr


Bill Daly, deputy commissioner of the NHL, and Steve Fehr of the NHL Players Assn., address the media following negotiations earlier this month.
(Bruce Bennett / Getty Images / December 4, 2012)





































































An amended collective bargaining proposal made by the NHL late Thursday to the players union includes a deadline to open training camps by Jan. 12 for a Jan. 19 start to the season or the 2012-13 season will be canceled, according to a source with knowledge of the matter but not authorized to speak about it publicly.


The source also confirmed earlier reports by many media outlets, led by ESPN.com, that the league had softened its stance on several key issues that had fueled the two sides' differences.


A Jan. 19 start would allow for a 48-game season, as the league played following a labor dispute that delayed the 1994-95 season.





Players are expected to discuss the proposal via conference call Friday and will probably make a counterproposal. NHL Deputy Commissioner Bill Daly said in a statement that the league had made “a new, comprehensive proposal” late Thursday, but he would not disclose the details.


It’s believed the NHL stayed firm on a 10-year term for the next labor deal, with an opt-out clause after eight years. Its “make-whole” offer of $300 million also remains intact as a means of easing players’ transition from last season’s 57% share of hockey-related revenues to a 50-50 split.


The NHL, which had previously proposed a five-year limit on player contracts with an exception of seven-year deals for teams to re-sign their own free agents, proposed a six-year limit while keeping the seven-year exception. It also increased the year-to-year variance allowed within a contract to 10% from 5% and would allow each team to buy out one player as a “compliance” issue as the new labor deal goes into effect. The amount of that player’s contract would not count against the team’s salary cap figure but would count toward players’ share of hockey-related revenues.


The salary cap next season would be set at $60 million and there would be no limit on escrow. The NHl Players Assn. had wanted a limit on escrow and had wanted buyouts, so it remains to be seen if players will accept the league’s latest proposal on that point.


ALSO:


Rafael Nadal pulls out of the Australian Open


Contest winners to join Beyonce onstage at Super Bowl


Matt Leinart says he deserves the start this week for Raiders






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Autodesk's Partnership With Organovo Will Lead to Printable Organs — But Not Soon



Autodesk is developing CAD tools that can design new blood vessels, liver tissue and other replacement parts for the human body in collaboration with 3-D bioprinter company Organovo. After their recent announcement about the project, the principals from each side have gone into detail about their excitement for the partnership.


The pairing will be a dramatic development for Organovo. Their bioprinters allow scientists to deposit cells and grow functional human tissues for use in medical research. They’re amazingly powerful 21st-century tools, but run on software left over from the Apollo era. Every time a scientist wants to print something, they have to write a script from scratch and run it from the command line. Instead of dreaming up new experiments, biologists have been kept busy debugging code.


“We already work at the intersection of enough disciplines that developing software was not something we thought was a good idea,” says Keith Murphy, CEO of Organovo. “Having 3-D design software will help scientists get to experiments faster, as well as make it easier for external academic experts to approach the our systems.”


Enter Autodesk. The CAD software giant has become ubiquitous in many professional realms, from architecture to industrial design. Meanwhile, their software has been used in the last 17 movies to win the Academy Award for best visual effects, including simulating the lifelike creatures from Avatar. And now with the new partnership, they’re developing programs that will actually create living things by supplying their software expertise to the bioprinter hardware manufacturer.


“Anything that’s been designed or built in the last 20 years, from buildings to cars to tables, would likely involve our software, but all of that is dead, inert,” says Carlos Olguin, leader of Autodesk’s 14-person Bio/Nano/Programmable Matter group. “Life is becoming a nascent design space in an engineering sense. It’s subject to specs, subject to QA, it’s repeatable. Biology is becoming an engineering discipline.”


Integration for the partnership will begin in earnest in 2013, but before we see scientific breakthroughs, though, there will be a period of catch up. “In many ways the first project is making a lateral transfer of technology.” says Olguin. “The level of maturity for bioprinting software is at the command line. Even if the first version of the software is just the UI, parametric modeling, and tools that have been used for the last 10-15 years in CAD packages, it will represent a huge improvement over the current state of the art.”


“Our scientists are very interested in getting to this first step, applications of things that have been traditional in 3-D software.” says Murphy. “For example, a challenge we have is that we don’t know what tool paths are the best. Using these tools in the design process will help us think through the possibilities and repeat things that work well more quickly.”


Olguin believes this will force Autodesk engineers to think differently. “This is different than traditional design process where you can model something that stays in the shape you specify,” he says. “With this process, stem cells are deposited layer by layer to create a construct and the designer or engineer sets constraints to create emergent behaviors.”



While this all sounds awesome, the big question remains “When can I print a spare kidney?”


The answer is unsatisfying. Even moderately complex structures, like patches of heart muscles to repair damage from heart attacks are decades out. Still, progress is still being made. “One of the dramatic things we did was to make blood vessels made from a patient’s own cells, comprised entirely of human cells, that expand and contract as expected and have reached a strength that’s implantable, though they are not yet implanted.” says Murphy.


The first “apps” on the Organovo platform will be simple tissues which could be ready for clinical trials in just 5 or 6 years. This is an eternity in smartphone cycles, but is a breakneck pace in healthcare. Until then, Organovo will continue to serve researchers at pharma companies that give the public 3-D printer company a steady stream of revenue, a fact Murphy says is a “fairly novel thing for an early stage life science company.”


Organovo also has a strong academic track record including partnerships with Stanford and Harvard along with a string of published papers that have the biomedical community abuzz. Ultimately, Murphy’s primary goal is getting more people experimenting. “For me it’s allowing greater access to our platform. The bottom line is it needs to be more accessible, faster to more people.”


Unfortunately for those who want to play Dr. Frankenstein, it’s unlikely that this software or the Organovo printer will be released for consumers or hobbyists anytime soon. However, Murphy sees a future where Organovo becomes an on-demand resource for the biomaterials community — a sort of Shapeways for skin tissue.


But he puts the whole project into perspective. “If you think about 3-D printing, that market has just hit a tipping point where it can deliver $1,000-10,000 devices that work reliably. We’re on the other side of that curve, closer to punch cards that laptops.”


Photos: Organovo


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Katie Holmes’ Broadway play ‘Dead Accounts’ closes






NEW YORK (AP) — Katie Holmes‘ return to Broadway will be much shorter than she would have liked.


The former Mrs. Cruise‘s play “Dead Accounts” will close within a week of the new year. Producers said Thursday that Theresa Rebeck‘s drama will close on Jan. 6 after 27 previews and 44 performances.






The show, which opened to poor reviews on Nov. 29, stars Norbert Leo Butz as Holmes’ onstage brother who returns to his Midwest home with a secret. Rebeck created the first season of NBC’s “Smash” and several well-received plays including “Seminar” and “Mauritius.”


Holmes, who became a star in the teen soap opera “Dawson’s Creek,” made her Broadway debut in the 2008 production of “All My Sons.” She was married to Tom Cruise from 2006 until this year.


___


Online: http://www.deadaccountsonbroadway.com


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Surgery Returns to NYU Langone Medical Center


Chang W. Lee/The New York Times


Senator Charles E. Schumer spoke at a news conference Thursday about the reopening of NYU Langone Medical Center.







NYU Langone Medical Center opened its doors to surgical patients on Thursday, almost two months after Hurricane Sandy overflowed the banks of the East River and forced the evacuation of hundreds of patients.




While the medical center had been treating many outpatients, it had farmed out surgery to other hospitals, which created scheduling problems that forced many patients to have their operations on nights and weekends, when staffing is traditionally low. Some patients and doctors had to postpone not just elective but also necessary operations for lack of space at other hospitals.


The medical center’s Tisch Hospital, its major hospital for inpatient services, between 30th and 34th Streets on First Avenue, had been closed since the hurricane knocked out power and forced the evacuation of more than 300 patients, some on sleds brought down darkened flights of stairs.


“I think it’s a little bit of a miracle on 34th Street that this happened so quickly,” Senator Charles E. Schumer of New York said Thursday.


Mr. Schumer credited the medical center’s leadership and esprit de corps, and also a tour of the damaged hospital on Nov. 9 by the administrator of the Federal Emergency Management Agency, W. Craig Fugate, whom he and others escorted through watery basement hallways.


“Every time I talk to Fugate there are a lot of questions, but one is, ‘How are you doing at NYU?’ ” the senator said.


The reopening of Tisch to surgery patients and associated services, like intensive care, some types of radiology and recovery room anesthesia, was part of a phased restoration that will continue. Besides providing an essential service, surgery is among the more lucrative of hospital services.


The hospital’s emergency department is expected to delay its reopening for about 11 months, in part to accommodate an expansion in capacity to 65,000 patient visits a year, from 43,000, said Dr. Andrew W. Brotman, its senior vice president and vice dean for clinical affairs and strategy.


In the meantime, NYU Langone is setting up an urgent care center with 31 bays and an observation unit, which will be able to treat some emergency patients. It will initially not accept ambulances, but might be able to later, Dr. Brotman said. Nearby Bellevue Hospital Center, which was also evacuated, opened its emergency department to noncritical injuries on Monday.


Labor and delivery, the cancer floor, epilepsy treatment and pediatrics and neurology beyond surgery are expected to open in mid-January, Langone officials said. While some radiology equipment, which was in the basement, has been restored, other equipment — including a Gamma Knife, a device using radiation to treat brain tumors — is not back.


The flooded basement is still being worked on, and electrical gear has temporarily been moved upstairs. Mr. Schumer, a Democrat, said that a $60 billion bill to pay for hurricane losses and recovery in New York and New Jersey was nearing a vote, and that he was optimistic it would pass in the Senate with bipartisan support. But the measure’s fate in the Republican-controlled House is far less certain.


The bill includes $1.2 billion for damage and lost revenue at NYU Langone, including some money from the National Institutes of Health to restore research projects. It would also cover Long Beach Medical Center in Nassau County, Bellevue, Coney Island Hospital and the Veterans Affairs hospital in Manhattan.


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